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However, GLP-1 drugs have surged in popularity due to their ability to support major weight loss and reduce risks for chronic conditions, including heart disease
For example, Medicare Part D patient enrollments expire at the conclusion of each calendar year
A handful of studies showed that GLP-1RAs induce pancreatic inflammation, cellular proliferation and intraepithelial neoplasia (PanIN).112114 One study found an association between the DPP-4I sitagliptin and pancreatitis, ductal cell replication and metaplasia in a rat model of diabetes.115 However, the majority of animal studies did not find any effect of GLP-1RAs or DPP-4Is on pancreatic physiology, even with a 240 times increased dose.116122 Notably, some studies even suggested that GLP-1RAs decreases inflammation and malignant degeneration.114 ,123125 Few human histological studies are available
We recommend balanced, protein-forward meals, fiber, hydration, and realistic movement
Mol Cell Endocrinol 339(1-2):144150
